Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is it possible to develop pan-arthropod vaccines?

J Santiago Mejia1, Jeanette V Bishop, Richard G Titus

  • 1Department of Microbiology, Immunology and Pathology, Colorado State University, 1619 Campus Delivery, Fort Collins, CO 80523, USA. jsmejia@colostate.edu

Trends in Parasitology
|June 21, 2006
PubMed
Summary

Developing a pan-arthropod vaccine targeting conserved N- and O-linked glycans is a novel strategy. Genetically modified Drosophila melanogaster cells can produce these glycans for potential use in anti-vector vaccines.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Progesterone supplementation in cattle hastens conceptus development and secretion of pregnancy-associated glycoproteins.

Biology of reproduction·2026
Same author

Identification of ovine proteins targeted by pregnancy-induced ISGylation and inference on function I: endometrium†.

Biology of reproduction·2026
Same author

Identification of transcriptome markers associated with in vitro bovine embryo quality in single embryos and biopsies†.

Biology of reproduction·2025
Same author

Postnatal Epigenetic Alterations in Calves Persistently Infected with Bovine Viral Diarrhea Virus.

Viruses·2025
Same author

Postnatal epigenetic differences in calves following transient fetal infection with bovine viral diarrhea virus.

BMC genomics·2025
Same author

Early identification of bovine pregnancy status and embryonic mortality†.

Biology of reproduction·2025

Area of Science:

  • Immunology and Parasitology
  • Molecular Biology and Genetics
  • Vector-Borne Disease Control

Background:

  • Hematophagous arthropods transmit numerous diseases, necessitating effective control strategies.
  • Current anti-vector vaccines primarily target species-specific arthropod saliva or midgut components.
  • Developing broadly effective vaccines against diverse arthropod vectors remains a significant challenge.

Purpose of the Study:

  • To explore an alternative strategy for anti-vector vaccines targeting conserved epitopes across arthropod species.
  • To investigate N- and O-linked glycans on arthropod glycoproteins as potential pan-arthropod vaccine targets.
  • To assess the feasibility of using genetically modified Drosophila melanogaster cells for glycan synthesis and delivery.

Main Methods:

Related Experiment Videos

  • Utilizing genetically modified Drosophila melanogaster (fruit fly) cell lines.
  • Engineering these cells for the synthesis of specific arthropod N- and O-linked glycans.
  • Evaluating the potential of these engineered cells to deliver synthesized glycans to vertebrate hosts.

Main Results:

  • Genetically modified Drosophila melanogaster cells can be engineered to produce arthropod-specific N- and O-linked glycans.
  • This approach offers a potential platform for generating conserved glycan antigens for vaccine development.
  • The study discusses the implications for a pan-arthropod vaccine strategy.

Conclusions:

  • N- and O-linked glycans represent conserved targets for a pan-arthropod vaccine approach.
  • Genetically modified Drosophila melanogaster cells provide a viable system for synthesizing and delivering these glycans.
  • This strategy holds promise for developing novel vaccines against a broad range of arthropod-borne diseases.