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Inhaled steroids do not decrease bone mineral density but increase risk of fractures: data from the GIUMO Study

M Sosa1, P Saavedra, C Valero

  • 1University of Las Palmas de Gran Canria, Hospital University Insular, Bone Metabolic Unit, Apartado 550, 35080 Las Palmas de Gran Canaria, Canary Islands, Spain. manuelsosah@canariastelecom.com

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|June 21, 2006
PubMed
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This summary is machine-generated.

Inhaled steroids for asthma do not affect bone mineral density (BMD). However, women using inhaled steroids have a higher risk of fractures, suggesting a potential link between inhaled corticosteroid use and bone health.

Area of Science:

  • Pulmonology
  • Endocrinology
  • Orthopedics

Background:

  • Systemic steroids are known to negatively impact bone health.
  • Evidence regarding the effects of inhaled steroids on bone metabolism and fracture risk is limited.
  • Bronchial asthma management often involves inhaled corticosteroid therapy.

Purpose of the Study:

  • To investigate the effects of inhaled steroids on bone mineral density (BMD) in women with bronchial asthma.
  • To assess the association between inhaled steroid use and fracture prevalence in this population.

Main Methods:

  • A cross-sectional study involving 105 women with bronchial asthma treated with inhaled steroids and 133 control participants.
  • Bone mineral density (BMD) was measured using quantitative ultrasonography (QUS) at the calcaneus and dual X-ray absorptiometry (DXA) at the lumbar spine and proximal femur.

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  • Fracture prevalence was compared between the patient and control groups, with age-adjusted odds ratios calculated.

    • Main Results:

    • No statistically significant differences in BMD were observed between women with bronchial asthma using inhaled steroids and the control group, as measured by both DXA and QUS.
    • A higher prevalence of fractures was found in women with bronchial asthma compared to controls.
    • An age-adjusted odds ratio of 2.79 (95% CI: 1.19-6.54) indicated an increased risk of fracture in the bronchial asthma group.

    Conclusions:

    • Inhaled steroids, commonly used for asthma treatment, do not appear to negatively impact bone mineral density.
    • Despite no effect on BMD, inhaled steroid use in women with bronchial asthma is associated with an elevated risk of fractures.
    • Further research is warranted to elucidate the mechanisms behind the increased fracture risk in patients using inhaled corticosteroids.