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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
A single-center experience with inflammatory breast cancer, 1985-2003
Rory L Smoot1, Cody A Koch, Amy C Degnim
1Department of Surgery, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA.
Archives of Surgery (Chicago, Ill. : 1960)
|June 21, 2006
Summary
Survival from inflammatory breast cancer (IBC) remains poor. While adenopathy and radiotherapy impact outcomes, the sequence of initial therapy does not improve survival in IBC patients.
Area of Science:
- Oncology
- Breast Cancer Research
- Clinical Outcomes
Background:
- Inflammatory breast cancer (IBC) is an aggressive form of breast cancer.
- Up-front surgery is hypothesized to improve survival in IBC patients.
Purpose of the Study:
- To evaluate the impact of initial therapy sequence on survival outcomes in inflammatory breast cancer (IBC).
Main Methods:
- Retrospective cohort study of 128 primary IBC patients diagnosed between 1985 and 2003.
- Analysis included all-cause and disease-free survival.
- Multivariate analysis was used to identify significant prognostic factors.
Main Results:
- The overall 5-year survival rate was 42%, with a 5-year disease-free survival of 21%.
- Multivariate analysis identified menopausal status as a key factor for recurrence.
- Palpable adenopathy was associated with decreased survival, while radiotherapy correlated with improved survival.
Conclusions:
- Survival for inflammatory breast cancer (IBC) remains suboptimal.
- While adenopathy and radiotherapy influence survival, the initial therapeutic sequence did not demonstrate an association with improved outcomes in this cohort.
