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Is rhinosinusitis a cause of asthma?
1Asthma and Allergy Center, DuPage Medical Group, Glen Ellyn, IL, USA. Brain.Smart@Dupagemd.com
Clinical Reviews in Allergy & Immunology
|June 21, 2006
Summary
Rhinosinusitis can trigger asthma, especially without polyps or eosinophilic inflammation. However, rhinosinusitis with polyps and eosinophilia shares underlying mechanisms with asthma, indicating complex links between these respiratory conditions.
Area of Science:
- Immunology
- Otolaryngology
- Pulmonology
Background:
- Strong association exists between rhinosinusitis and asthma.
- The exact relationship remains unclear: trigger or common process?
Purpose of the Study:
- To explore the complex relationship between rhinosinusitis and asthma.
- To differentiate the roles of rhinosinusitis subtypes in asthma.
Main Methods:
- Review of evidence linking rhinosinusitis and asthma.
- Analysis of proposed mechanisms including reflexes, inflammation, and shared pathways.
Main Results:
- Rhinosinusitis without polyps/eosinophilia may trigger asthma.
- Rhinosinusitis with polyps/eosinophilia shares asthma's mechanisms.
- Naso-pharyngo-bronchial reflexes, inflammation, and bone marrow pathways are implicated.
Conclusions:
- Rhinosinusitis is not a single entity; its phenotype dictates its relationship with asthma.
- Understanding these distinct pathways is crucial for effective treatment of both conditions.
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