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L-dopa potentiating analogs of Pro-Leu-Gly-NH2 with oral efficacy
H P Albrecht1, H P Hofman, G Klebe
1BASF, Hauptlaboratorium, Ludwigshafen, F.R.G.
Bollettino Chimico Farmaceutico
|February 1, 1991
Abstract:
Chemical modification of PLG, comprising replacement of proline or/and leucine by unnatural amino acids led to analogs with high oral efficacy. The most active analog identified in the course of our works was 1-prolyl-2-phenyl-1-2-aminobutanoylglycinamide (Doreptide). Doreptide is presently further evaluated as a new drug for the treatment of Parkinson's disease.