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Updated: Aug 7, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
Capillary electrophoresis for the analysis of small-molecule pharmaceuticals
Kevin Altria1, Alex Marsh, Cari Sänger-van de Griend
1GlaxoSmithKline Research & Development, Harlow, Essex, UK. kevin.d.altria@gsk.com
Abstract:
This paper reviews the application of CE to the analysis of small-molecule pharmaceuticals. The areas of pharmaceutical analysis covered are enantiomer separation, the analysis of small molecules such as amino acids or drug counter-ions, pharmaceutical assay, determination of related substances and physicochemical measurements such as log P and pK(a) of compounds. The different electrophoretic modes available and their advantages for pharmaceutical analysis are described. Recent applications of CE for each subject area are tabulated with electrolyte details.
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