Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Quantitative diffusion imaging in breast cancer: a clinical prospective study.

Erika Rubesova1, Anne-Sophie Grell, Viviane De Maertelaer

  • 1Department of Radiology, CHU Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium. erubesova@yahoo.com

Journal of Magnetic Resonance Imaging : JMRI
|June 21, 2006
PubMed
Summary

Apparent diffusion coefficient (ADC) measurements can help differentiate benign from malignant breast lesions. A specific ADC threshold showed 86% sensitivity and specificity, improving breast MRI accuracy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk Factors Associated with the Emergence of Multidrug-Resistant Bacteria and Fungal Infections in Walled-Off Pancreatic Necrosis.

Antibiotics (Basel, Switzerland)·2026
Same author

Exploring the association between BMI and liver fat in children: a study using ultrasound-derived fat fraction (UDFF).

Pediatric radiology·2025
Same author

Prenatal Diagnosis of a Large Lymphovascular Malformation.

NeoReviews·2025
Same author

Lactate and gastrointestinal complications during enteral nutrition in pediatric ECMO patients: a retrospective cohort study.

European journal of pediatrics·2025
Same author

Liver Fibrosis: Diving into Microstructure with Diffusion-weighted Imaging.

Radiology·2024
Same author

Contrast media viscosity and its potential effect on the diagnosis of vesicoureteral reflux in children.

European radiology·2024

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Breast lesions require accurate differentiation between benign and malignant types.
  • Magnetic Resonance Imaging (MRI) is a key modality for breast lesion assessment.
  • Diffusion-weighted imaging (DWI) provides functional information about tissue microstructure.

Purpose of the Study:

  • To investigate the correlation between apparent diffusion coefficient (ADC) and breast lesion pathology.
  • To assess the accuracy of ADC in distinguishing malignant from benign breast lesions.
  • To establish a diagnostic threshold value for ADC in breast MRI.

Main Methods:

  • Seventy-eight patients with 110 undefined breast lesions underwent contrast-enhanced 3D-FLASH MRI and EPI DWI.
  • Regions of interest (ROIs) were placed on ADC maps derived from subtraction images.

Related Experiment Videos

  • Inter- and intraobserver variability was assessed for reproducibility.

    • Main Results:

    • Pathological analysis confirmed 22 benign and 65 malignant lesions.
    • Mean ADC values differed significantly: 0.95 x 10(-3)mm(2)/s for malignant and 1.51 x 10(-3)mm(2)/s for benign lesions.
    • Receiver operating characteristic (ROC) analysis identified an ADC threshold of 1.13 x 10(-3)mm(2)/s with 86% sensitivity and 86% specificity.

    Conclusions:

    • Apparent diffusion coefficient (ADC) shows potential in differentiating benign and malignant breast lesions.
    • ADC measurement can enhance the overall diagnostic specificity of breast MRI.
    • The established ADC threshold aids in classifying breast lesions, potentially reducing unnecessary biopsies.