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Published on: December 15, 2015
Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials
Francisco Balas1, Miguel Manzano, Patricia Horcajada
1Departamento de Química Inorganica y Bioinorganica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Abstract:
Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering.
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