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Synthesis of mixed sequence borane phosphonate DNA

Heather Brummel McCuen1, Mary S Noé, Agnieszka B Sierzchala

  • 1Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309-0215, USA.

Journal of the American Chemical Society
|June 22, 2006
PubMed
Summary

A new solid-phase synthesis method enables the creation of borane phosphonate DNA. This breakthrough allows for the first time the synthesis of DNA with mixed or exclusively borane phosphonate linkages.

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