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Updated: Aug 7, 2026
06:46
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
Association between infectious diseases and type 1 diabetes: a case-crossover study
Ze Yang1, Fan Zhou, Janice Dorman
1Institute of Geriatrics and Beijing Hospital, Ministry of Health, Beijing, China.
Pediatric Diabetes
|June 22, 2006
Summary
Infections significantly increase the risk of developing type 1 diabetes (T1D) shortly after illness. This transient risk elevation highlights infections as a potential trigger for T1D onset.
Area of Science:
- Immunology
- Endocrinology
- Epidemiology
Background:
- Type 1 diabetes (T1D) is an autoimmune disease with complex etiology.
- The role of infectious diseases as potential triggers for T1D requires further investigation.
Purpose of the Study:
- To estimate the relative risk of T1D onset following infectious diseases.
- To determine the temporal relationship between infections and T1D development.
Main Methods:
- A case-crossover study design was utilized.
- Data were collected from 260 T1D patients in a Chinese registry.
- Infectious disease occurrences were assessed via medical records and parental interviews up to 407 days prior to T1D onset.
Main Results:
- 18% of patients reported infectious diseases preceding T1D onset.
- A markedly elevated relative risk (10.1) of T1D was observed immediately after infections.
- The increased risk was transient, peaking within 42 days post-infection.
Conclusions:
- Infectious diseases are associated with a significant, temporary increase in T1D risk.
- Infections act as a potential precipitating factor in T1D development.
- Understanding this link can inform T1D prevention and management strategies.
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