Related Experiment Video
Updated: Jan 26, 2026

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland
Published on: August 4, 2022
Cytosolic calcium oscillations in submandibular gland cells
Li Su1, Chun-yan Ma, Yan-dong Zhou
1Institute of Cell Biology, Beijing Normal University, Beijing 100875, China.
Abstract:
Calcium oscillations can, by default, encode diverse and specific signals by different modes of modulation. Frequency modulation is illustrated by the activation of calcium/calmodulin-dependent protein kinase II at unit Hz, and of calcineurin at 10 mHz frequencies, respectively. The submandibular gland secretory axis is characterized by both potassium and osmolarity gradients from the luminal side of the secretory cells. Such gradients may play significant physiological roles through the feedback modulation of cholinergic stimulation. High potassium transforms plateau calcium increases induced by cholinergic stimulation of the submandibular acinar cells into oscillatory calcium increases. The ductal cells may have similar mechanisms of feedback modulation both by high potassium and by hypoosmolarity. Such feedback mechanisms could modulate the decision-making process for determining which secretory products are selectively released after nerve stimulation.
Related Concept Videos
Oscillations In An LC Circuit
Forced Oscillations
Damped Oscillations
Although friction and other non-conservative...
Oscillations about an Equilibrium Position
Exocrine Glands: Unicellular and Multicellular Glands
The Thyroid Gland
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...

