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Related Experiment Videos

Tissue-specific sensitivity to AID expression in transgenic mouse models.

Francesca Rucci1, Leonardo Cattaneo, Veronica Marrella

  • 1Human Genome Department, Istituto di Tecnologie Biomediche, CNR, Segrate (MI), Italy.

Gene
|June 22, 2006
PubMed
Summary

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Activation-induced cytidine deaminase (AID) drives thymic lymphomas in mice. AID

Area of Science:

  • Immunology
  • Molecular Biology
  • Oncology

Background:

  • Activation-induced cytidine deaminase (AID) is crucial for immunoglobulin gene diversification via somatic hypermutation.
  • AID's role in tumorigenesis is suggested by its mutagenic activity on reporter and non-immunoglobulin genes.
  • Previous studies with ubiquitous AID expression showed T lymphomas and lung adenomas, but not consistently.

Purpose of the Study:

  • To investigate the tissue-specific oncogenic potential of AID using different promoter systems in transgenic mice.
  • To determine if AID's tumorigenic activity is dependent on specific cellular environments or factors.

Main Methods:

  • Generated transgenic mice expressing AID under the control of the lck, HTLV-I, and MMTV promoters.
  • Monitored transgenic mice for tumor development over extended periods.

Related Experiment Videos

  • Observed clinical presentation and performed pathological examination of affected mice.

    • Main Results:

    • Mice expressing AID under the lck promoter (lck/AID) efficiently developed thymic lymphomas.
    • HTLV-I/AID transgenic mice showed no tumor development after two years.
    • MMTV/AID founder mice exhibited an atypical clinical course without mammary tumors.

    Conclusions:

    • AID's oncogenic potential appears to be influenced by the cellular context, with thymocytes being particularly susceptible.
    • The presence of specific factors in thymocytes or physiological double-strand breaks (DSBs) may be necessary for AID to exert its full mutagenic and transforming activity.