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Status epilepticus caused by a myxoedema coma.

H J Jansen1, S R Oedit Doebé, E S Louwerse

  • 1Department of Intensive Care, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands. Henry_jansen@hotmail.com

The Netherlands Journal of Medicine
|June 22, 2006
PubMed
Summary

Severe hypothyroidism can rarely cause status epilepticus, a serious neurological condition. This case highlights the high mortality rate associated with myxedema coma, even with treatment.

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Area of Science:

  • Endocrinology
  • Neurology

Background:

  • Thyroid hormone deficiency can lead to significant neurological dysfunction.
  • Myxedema coma is a severe manifestation of hypothyroidism with a high mortality rate.

Observation:

  • A 63-year-old woman presented with status epilepticus, coma, and hypoventilation.
  • Initial assessment suggested a primary neurological cause, but hypothermia prompted further investigation.
  • The patient was diagnosed with severe hypothyroidism.

Findings:

  • The patient experienced status epilepticus, a rare neurological complication of severe hypothyroidism.
  • This presentation is highly unusual, with only two reported cases of myxedema coma manifesting this way.
  • Despite treatment, the patient unfortunately died.

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Implications:

  • This case underscores the critical importance of considering endocrine disorders, particularly severe hypothyroidism, in patients with unexplained neurological emergencies.
  • Early diagnosis and management of myxedema coma are crucial, though outcomes remain poor.
  • Further research may be needed to understand and improve the management of rare neurological presentations of hypothyroidism.