Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental models for psoriasis.

G G Krueger1, C M Jorgensen

  • 1Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City 84132, USA.

The Journal of Investigative Dermatology
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining drug-free remission of skin disease in patients with plaque psoriasis.

The British journal of dermatology·2019
Same author

Systemic corticosteroid use in psoriasis: a national survey of board-certified dermatologists.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018
Same author

Correlation of psoriasis activity with socioeconomic status: cross-sectional analysis of patients enrolled in the Psoriasis Longitudinal Assessment and Registry (PSOLAR).

The British journal of dermatology·2018
Same author

Drug survival of biologic therapy in a large, disease-based registry of patients with psoriasis: results from the Psoriasis Longitudinal Assessment and Registry (PSOLAR).

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

Onset of psoriatic arthritis during ustekinumab treatment for psoriasis: a case series of seven patients.

The British journal of dermatology·2015
Same author

Long-term efficacy and safety of ustekinumab, with and without dosing adjustment, in patients with moderate-to-severe psoriasis: results from the PHOENIX 2 study through 5 years of follow-up.

The British journal of dermatology·2014

Fibroblasts from psoriatic skin can drive psoriasis development. These cells, especially from unaffected areas, signal normal skin cells to proliferate, suggesting a soluble factor is responsible for the psoriasiform phenotype.

Area of Science:

  • Dermatology and cell biology
  • Investigating the cellular mechanisms of psoriasis

Background:

  • Psoriasis is characterized by epidermal hyperproliferation.
  • Fibroblasts play a role in epidermal proliferation and differentiation.
  • Previous research suggested psoriatic fibroblasts might influence epidermal changes.

Purpose of the Study:

  • To define the in vitro characteristics of psoriatic skin cells.
  • To investigate the role of fibroblasts from psoriatic patients in epidermal abnormalities.
  • To determine if psoriatic fibroblasts can induce a psoriasiform phenotype in normal keratinocytes.

Main Methods:

  • Cultured fibroblasts from involved and uninvolved psoriatic skin.
  • Assessed fibroblast proliferation rates in the presence of normal or psoriatic human serum.

Related Experiment Videos

  • Developed an interactive skin equivalent system to test fibroblast-keratinocyte interactions.

    • Main Results:

    • Fibroblasts from psoriatic patients (both involved and uninvolved sites) showed increased proliferation rates.
    • Fibroblasts from uninvolved psoriatic sites exhibited the highest responsiveness.
    • Using the skin equivalent system, psoriatic fibroblasts induced enhanced outgrowth in normal keratinocytes, with uninvolved fibroblasts causing the most significant changes.

    Conclusions:

    • Fibroblasts from psoriatic subjects can induce a psoriasiform phenotype in normal keratinocytes.
    • This induction occurs through a soluble mediator acting over distance.
    • Psoriatic fibroblasts, particularly from uninvolved skin, are key players in driving psoriasis pathogenesis.