Prevalence of complications in children with chronic kidney disease according to KDOQI

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

H Wong1, K Mylrea, J Feber

  • 1Department of Pediatrics, Division of Nephrology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.

Kidney International
|June 22, 2006
PubMed

Insights

This study analyzed chronic kidney disease (CKD) complications in 366 children. Findings reveal differences in causes and prevalence compared to adults, suggesting guideline modifications for pediatric care.

Area of Science:

  • Pediatric Nephrology
  • Chronic Kidney Disease Research
  • Clinical Guidelines

Background:

  • The Kidney Disease Outcome and Quality Initiative (KDOQI) guidelines for chronic kidney disease (CKD) were established in 2002, primarily based on adult data.
  • The prevalence of CKD complications in pediatric populations remains largely uncharacterized.
  • Understanding these differences is crucial for appropriate pediatric CKD management.

Purpose of the Study:

  • To determine the prevalence of CKD complications across all stages in a pediatric cohort.
  • To compare the causes and complications of CKD in children versus adults.
  • To evaluate the applicability of current KDOQI guidelines to pediatric CKD patients.

Main Methods:

  • A cross-sectional study was conducted on 366 pediatric patients with CKD.
  • Patients were staged according to KDOQI guidelines based on serum cystatin C levels for estimated renal function.
  • Prevalence of complications including hypertension, anemia, proteinuria, metabolic bone disease, and growth failure was analyzed.

Main Results:

  • Uropathies (31%) and glomerular disease (27%) were the leading causes of CKD.
  • High prevalence of complications was observed: hypertension (70.2%), anemia (36.6%), metabolic bone disease (16.9%), and proteinuria (11.5%).
  • Anemia and metabolic bone disease were frequent even in early stages (GFR >60 ml/min/1.73 m2), and growth failure (11.5%) was common.

Conclusions:

  • The study supports KDOQI guidelines for defining and staging pediatric CKD but highlights significant differences from adult data.
  • Pediatric CKD presents unique causes and complication profiles compared to adults.
  • Modifications to KDOQI guidelines are recommended to better address the specific needs of children with CKD.

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