Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiovascular factors explain genetic background differences in VO2max.

Jane L P Roy1, Gary R Hunter, Jose R Fernandez

  • 1Department of Human Studies, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

American Journal of Human Biology : the Official Journal of the Human Biology Council
|June 22, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of High-Impact Exercise on Bone Marker Concentrations During Controlled Low Energy Availability in Recreational Female Runners.

Calcified tissue international·2026
Same author

Higher education institutions and the use of marketing-mix choice architecture strategies to encourage plant-rich menu options and sustainable dietary patterns: a scoping review.

Frontiers in nutrition·2026
Same author

Size of Biceps Femoris Long Head Muscle Is Related to Running Economy in Male Recreational Runners.

Sports (Basel, Switzerland)·2025
Same author

Accelerometer measurement error in a randomized physical activity intervention trial in breast cancer survivors was nondifferential but attenuated the intervention effect.

The international journal of behavioral nutrition and physical activity·2025
Same author

Mitochondrial coupling efficiency and myofiber type related to blood pressure 22 h after high-intensity exercise in premenopausal women.

European journal of applied physiology·2025
Same author

Association Between Antioxidant Capacity and Vascular Hemodynamics in Premenopausal Women Following Exercise Training.

Journal of clinical hypertension (Greenwich, Conn.)·2025
Same journal

Weight Perception Varies by Local Peer Body Size Norms Among US Adolescents.

American journal of human biology : the official journal of the Human Biology Council·2026
Same journal

Increased Vulnerability to Dehydration Due to Heat Stress and Drought Across Reproductive States for Pastoralist Women in Northern Kenya.

American journal of human biology : the official journal of the Human Biology Council·2026
Same journal

Connectedness to Nature, Ceremonial Participation, and Mental and Physical Health Among Rural and Urban Wixárika in Jalisco, Mexico.

American journal of human biology : the official journal of the Human Biology Council·2026
Same journal

Relationships Between Estradiol Levels and Vaginal Lactobacillus Abundance Across the Menstrual Cycles in Women.

American journal of human biology : the official journal of the Human Biology Council·2026
Same journal

Dam-Induced Displacement and Disruption Are Associated With Salivary Cortisol Concentration and Patterns of Diurnal Variation.

American journal of human biology : the official journal of the Human Biology Council·2026
Same journal

Ethnic Variability in Anthropometric Trajectories Across the Lifespan: Findings From a Nationwide Survey in Peru.

American journal of human biology : the official journal of the Human Biology Council·2026
See all related articles

Mitochondrial muscle oxidative capacity and oxygen delivery explain ethnic differences in maximal oxygen consumption (VO2max). These factors, not ethnicity itself, are key drivers of VO2max variations.

Area of Science:

  • Exercise Physiology
  • Human Physiology
  • Genetics

Background:

  • Ethnic disparities in cardiorespiratory fitness exist.
  • Maximal oxygen consumption (VO2max) is a key indicator of cardiorespiratory fitness.
  • Factors contributing to these ethnic differences require further investigation.

Purpose of the Study:

  • To investigate factors influencing ethnic differences in VO2max.
  • To compare VO2max and related physiological parameters between African American (AA) and European American (EA) women.
  • To identify predictors of VO2max variance.

Main Methods:

  • Participants: 20 AA and 30 EA sedentary women matched for body weight and fat-free mass (FFM).
  • Measurements: VO2max via graded treadmill test, submaximal oxygen consumption, heart rate, hemoglobin (Hb), muscle oxidative capacity (31P magnetic resonance spectroscopy ADP time constant), FFM (DXA), and genetic admixture.

Related Experiment Videos

  • Statistical analysis: Multiple regression modeling.

    • Main Results:

    • AA women exhibited significantly lower VO2max, Hb, and muscle oxidative capacity compared to EA women.
    • Submaximal oxygen pulse (O2Psubmax), ADP time constant, Hb, and ethnicity were significantly related to VO2max.
    • Muscle oxidative capacity and O2Psubmax independently predicted VO2max, explaining significant variance.

    Conclusions:

    • Mitochondrial muscle oxidative capacity and oxygen delivery (O2Psubmax) are primary determinants of VO2max.
    • These physiological factors, rather than ethnicity per se, account for observed ethnic differences in VO2max.
    • Future research should focus on these physiological mechanisms to understand and potentially mitigate fitness disparities.