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[Transient pancytopenia due to ticlopidine--a case report]
Marcin Grabowski1, Wojciech Barg, Anna Biełous-Wilk
1Katedra i Klinika Chorób Wewnetrznych i Alergologii Akademii Medycznej we Wrocławiu. mgrabow@alergol.am.wroc.pl
Polskie Archiwum Medycyny Wewnetrznej
|June 23, 2006
Summary
Ticlopidine can cause transient pancytopenia, a serious blood disorder. This case highlights the importance of careful consideration before prescribing ticlopidine due to potential severe hematologic adverse effects.
Area of Science:
- Hematology
- Pharmacology
- Clinical Medicine
Background:
- Ticlopidine is an antiplatelet medication used for cardiovascular event prevention.
- Adverse hematologic reactions are known, though infrequent, complications of ticlopidine therapy.
Observation:
- A 66-year-old woman developed transient pancytopenia after ticlopidine administration for heart failure prevention.
- Initial symptoms included a skin rash, leading to drug cessation, followed by septic shock, pneumonia, and severe neutropenia.
Findings:
- The patient experienced significant decreases in neutrophils, platelets, erythrocytes, and hemoglobin.
- Despite the severity, the patient recovered with antibiotic treatment and did not require blood transfusions.
Implications:
- This case underscores ticlopidine's potential for severe, albeit transient, pancytopenia.
- Physicians should carefully weigh the risks versus benefits of ticlopidine, considering its 0.8-2.3% incidence of severe hematologic effects.
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