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Related Experiment Videos

Poisoning with oxybutynin.

S Banerjee1, P A Routledge, S Pugh

  • 1Welsh National Poisons Unit, Llandough Hospital, Cardiff, South Glamorgan, UK.

Human & Experimental Toxicology
|May 1, 1991
PubMed
Summary
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This case report details oxybutynin poisoning in a 34-year-old female, highlighting significant anticholinergic effects and cardiac arrhythmias. The patient recovered fully with only symptomatic treatment.

Area of Science:

  • Pharmacology
  • Toxicology
  • Clinical Medicine

Background:

  • Oxybutynin is commonly prescribed for overactive bladder.
  • Anticholinergic toxicity can manifest with a range of symptoms.
  • Understanding overdose effects is crucial for clinical management.

Observation:

  • A 34-year-old female presented after ingesting 100 mg of oxybutynin.
  • Key symptoms included stupor, disorientation, agitation, mydriasis, dry skin, and urinary retention.
  • Cardiac monitoring revealed sinus tachycardia and persistent ventricular ectopics/bigeminy.

Findings:

  • The patient exhibited a classic anticholinergic toxidrome.
  • Sinus tachycardia resolved within 3 hours post-admission.
  • Ventricular arrhythmias persisted for 30 hours despite no specific antidote administration.

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Implications:

  • This case underscores the potential for severe anticholinergic toxicity with oxybutynin overdose.
  • Symptomatic management is effective for oxybutynin poisoning.
  • Clinicians should be vigilant for cardiac arrhythmias in anticholinergic overdose scenarios.