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Updated: Aug 7, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
[Coronary angiography: beyond coronary anatomy]
Armando Pérez de Prado1, Felipe Fernández-Vázquez, J Carlos Cuellas-Ramón
1Sección de Cardiología Intervencionista, Servicio de Cardiología, Hospital de León, Altos de Nava s/n, 24008 León, Spain. aperez@secardiologia.es
Insights
Coronary angiography can assess both epicardial and microvascular blood flow after myocardial infarction, offering valuable prognostic information beyond simple blood flow restoration.
Area of Science:
- Cardiology
- Medical Imaging
- Physiology
Background:
- Technical advances allow restoration of epicardial coronary artery blood flow in most myocardial infarction patients.
- Improved myocardial perfusion does not always follow restored blood flow, increasing interest in perfusion assessment.
- Conventional coronary angiography is a widely used technique for evaluating coronary artery blood flow.
Purpose of the Study:
- To evaluate the additional information provided by conventional coronary angiography regarding myocardial perfusion.
- To review data on epicardial and microvascular blood flow assessment using coronary angiography.
- To discuss the prognostic significance of these blood flow parameters.
Main Methods:
- Review of existing data on coronary angiography.
- Analysis of semiquantitative and quantitative assessment of epicardial coronary artery blood flow.
- Evaluation of microvascular blood flow assessment using coronary angiography.
Main Results:
- Coronary angiography provides data on both epicardial and microvascular blood flow.
- Quantitative and semiquantitative assessments of epicardial flow are possible.
- Microvascular function can be inferred from angiographic findings.
Conclusions:
- Conventional coronary angiography offers valuable insights into myocardial perfusion beyond epicardial flow.
- Assessment of both epicardial and microvascular components is crucial for understanding post-myocardial infarction outcomes.
- Angiographic assessment of blood flow has significant prognostic implications.
Abstract:
Although technical advances enable normal epicardial coronary artery blood flow to be restored in most patients suffering myocardial infarction, restoration of blood flow is not always followed by improved myocardial perfusion. Recently, therefore, interest in the assessment of myocardial perfusion has grown, and a number of different assessment methods are available. The aim of this article was to provide an evaluation of the additional information that can be obtained from the widely used technique of conventional coronary angiography. We present a review of the data on epicardial coronary artery blood flow (both semiquantitative and quantitative) and on microvascular blood flow that can be obtained using coronary angiography and discuss their prognostic significance.
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