Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adhesions that mediate invasion.

Mario Gimona1, Roberto Buccione

  • 1Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro, Italy. gimona@negrisud.it

The International Journal of Biochemistry & Cell Biology
|June 23, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Potency Assays for Therapeutic EVs: The Art of Congruence.

Journal of extracellular vesicles·2026
Same author

Current Perspective on Human Milk Derived Vesicles and Their Potential Therapeutic Use: A Scoping Review.

Journal of extracellular vesicles·2026
Same author

Corrigendum to "Exploring the role of extracellular vesicles in otorhinolaryngology: From diagnostics to therapeutic potential" [Int. J. Pharm. 692 (2026) 126634].

International journal of pharmaceutics·2026
Same author

Exploring the role of extracellular vesicles in otorhinolaryngology: From diagnostics to therapeutic potential.

International journal of pharmaceutics·2026
Same author

From Lab to Industry: Advancing the Translational Potential of Extracellular Vesicles Through the ISEV Translation, Regulation and Advocacy Committee (ISEV-TRA).

Journal of extracellular vesicles·2026
Same author

Anatomical implant region - a critical determinant for the osteogenic potency of small extracellular vesicles and rhBMP-2.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2025

Mammalian cells degrade the extracellular matrix using specialized structures called podosomes and invadopodia. These structures are crucial for cell migration in development and cancer metastasis.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Oncology

Background:

  • Cellular infiltration into new tissue requires overcoming the extracellular matrix (ECM) barrier.
  • Controlled ECM degradation is vital for embryonic development and metastatic tumor cell spread.
  • Podosomes and invadopodia are key cellular structures involved in localized ECM degradation.

Purpose of the Study:

  • To review recent advances in understanding focal ECM degradation by podosomes and invadopodia.
  • To discuss the role of these structures in cell migration.
  • To provide an outlook on future research directions.

Main Methods:

  • Literature review of recent studies on podosomes and invadopodia.
  • Analysis of cellular mechanisms underlying ECM degradation at adhesive and protrusive sites.

Related Experiment Videos

  • Discussion of implications for tissue crossing and metastasis.

    • Main Results:

    • Podosomes and invadopodia mediate localized ECM degradation.
    • These structures are essential for polarized cell migration across tissue boundaries.
    • Their function is conserved in both normal development and aggressive cancers.

    Conclusions:

    • Focal ECM degradation by podosomes and invadopodia is a fundamental process in cell migration.
    • Further research is needed to fully elucidate the principles governing this degradation.
    • Understanding these mechanisms could offer new therapeutic strategies for cancer metastasis.