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Related Concept Videos

Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...

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Related Experiment Video

Updated: Jun 9, 2026

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

Obesity and infection.

Matthew E Falagas1, Maria Kompoti

  • 1Alfa Institute of Biomedical Sciences, Athens, Greece. m.falagas@aibs.gr

The Lancet. Infectious Diseases
|June 23, 2006
PubMed
Summary
This summary is machine-generated.

Obesity impacts the immune system, increasing susceptibility to infections. Obese individuals face higher risks of various infections and severe complications, necessitating further research.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Public Health

Background:

  • Obesity is a global health concern linked to increased morbidity and mortality.
  • The intricate relationship between obesity and infection susceptibility requires comprehensive review.
  • Existing literature on obesity's impact on infection is fragmented.

Purpose of the Study:

  • To review the clinical aspects of the association between obesity and infection.
  • To synthesize current knowledge on how obesity influences immune responses and infection risk.
  • To identify gaps in understanding the burden of infectious diseases in obese populations.

Main Methods:

  • Systematic literature review of clinical studies.
  • Focus on studies examining the incidence and outcomes of infections in obese individuals.
  • Analysis of immune mediators and their role in obesity-related susceptibility.

Main Results:

  • Obesity demonstrably affects immune responses via various mediators, increasing infection susceptibility.
  • Obese individuals exhibit a higher likelihood of developing postoperative and nosocomial infections.
  • Data indicate a greater risk of severe complications from common infections in obese populations.

Conclusions:

  • Obesity is associated with increased susceptibility to and severity of infections.
  • Further large-scale prospective studies are essential to fully elucidate the infectious disease burden in obesity.
  • Understanding this relationship is critical for public health strategies and clinical management.