Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Chronic rejection in the heart.

Philip Hornick¹, Marlene Rose

¹Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College Hammersmith Campus, London, England.

Methods in Molecular Biology (Clifton, N.J.)

|June 23, 2006

Summary

Long-term heart transplant survival is limited by chronic rejection, a fibroproliferative disease causing graft vasculopathy. This process involves antibody and cell-mediated phases, impacting graft survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Leukocyte Adhesion Under Hemodynamic Flow Conditions.

Methods in molecular biology (Clifton, N.J.)·2017

Same author

The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis.

Blood·2012

Same author

Leucocyte adhesion under haemodynamic flow conditions.

Methods in molecular biology (Clifton, N.J.)·2010

Same author

Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial.

Lancet (London, England)·2010

Same author

Report from a consensus conference on the sensitized patient awaiting heart transplantation.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2009

Same author

Haemothorax.

British journal of hospital medicine (London, England : 2005)·2007

Area of Science:

Cardiovascular Science
Transplantation Immunology
Pathology

Background:

Cardiac transplantation survival has improved, but long-term graft survival remains a challenge.
Chronic rejection, or cardiac graft vasculopathy, is a fibroproliferative disease causing intimal thickening and coronary vessel occlusion.
This condition serves as a model for atherosclerosis and post-angioplasty restenosis.

Purpose of the Study:

To describe the histology and clinical sequelae of cardiac graft vasculopathy.
To highlight the role of alloantigen-dependent mechanisms in driving this disease.
To outline the three distinct phases of chronic rejection evolution.

Main Methods:

Review of histological and clinical data on cardiac graft vasculopathy.
Analysis of experimental studies, including adoptive transfer of immunoglobulin.
Examination of the role of endothelial damage and immune responses.

Main Results:

Cardiac graft vasculopathy is characterized by intimal thickening and vessel occlusion.
The disease progresses through antibody-mediated, cell-mediated, and tissue remodeling phases.
Experimental evidence suggests immunoglobulin transfer can induce intimal hyperplasia.

Conclusions:

Chronic rejection significantly limits long-term cardiac allograft survival.
Alloantigen-dependent mechanisms are key drivers of cardiac graft vasculopathy.
Endothelial damage is a critical initiating factor, with ongoing research into the roles of T cells and antibodies.

Related Experiment Videos