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Can .OH scavengers protect against direct UV-C damage in vivo?
1Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA 19102.
International Journal of Radiation Biology
|September 1, 1991
Abstract:
It has previously been shown that ethanol and tert-butanol protect poly(U) against strand breaks from pulsed laser ultraviolet (UV) photons (lambda = 248 nm). This protection is believed to be based on a modification of direct DNA damage, not on scavenging hydroxyl radicals. In this paper, several .OH scavengers were tested in vivo with Escherichia coli DNA repair-deficient mutants to see if protection could also be demonstrated with non-laser UV photons (lambda approximately 254 nm). No protection was observed.