Jove
Visualize
Contact Us

Related Experiment Videos

Direct and indirect allorecognition.

Philip Hornick1

  • 1Cardiothoracic Surgery, National Heart and Lung Institute, Imperial College Hammersmith Campus, London, England.

Methods in Molecular Biology (Clifton, N.J.)
|June 23, 2006
PubMed
Summary

Understanding acute and chronic rejection mechanisms is key for graft acceptance. The direct pathway dominates early transplant rejection, while the indirect pathway may drive chronic rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial.

Lancet (London, England)·2010
Same author

Haemothorax.

British journal of hospital medicine (London, England : 2005)·2007
Same author

Use of a skin stapler to repair penetrating cardiac injury.

Annals of the Royal College of Surgeons of England·2007
Same author

Tuberculous pericardial effusion after coronary artery bypass graft.

The Annals of thoracic surgery·2006
Same author

Chronic rejection in the heart.

Methods in molecular biology (Clifton, N.J.)·2006
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Immunology
  • Transplantation Biology
  • Allorecognition Mechanisms

Background:

  • Long-term graft acceptance is crucial in transplantation.
  • Acute and chronic rejection impede graft survival.
  • Understanding allorecognition pathways is fundamental.

Purpose of the Study:

  • To elucidate the roles of direct and indirect allorecognition pathways in transplantation.
  • To provide a comprehensive overview of graft rejection mechanisms.
  • To inform the design of strategies for promoting long-term graft acceptance.

Main Methods:

  • Review of in vitro experimental models.
  • Analysis of in vivo experimental models.
  • Examination of clinical data.

Main Results:

  • The direct allorecognition pathway is implicated in early post-transplant rejection (weeks).
  • The indirect allorecognition pathway may contribute to chronic rejection.
  • Both pathways are critical for understanding rejection dynamics.

Conclusions:

  • Differentiating the roles of direct and indirect pathways is essential for therapeutic strategies.
  • Targeting specific allorecognition pathways could improve graft survival.
  • Further research integrating experimental and clinical findings is warranted.

Related Experiment Videos