Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Positron emission tomography.

Gerd Muehllehner¹, Joel S Karp

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Physics in Medicine and Biology

|June 23, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Brain-gut axis imaging, motion correction with [ <sup>11</sup> C]-carfentanil total-body PET.

medRxiv : the preprint server for health sciences·2026

Same author

A multi-modal flow phantom for quantitative PET/Spectral CT.

bioRxiv : the preprint server for biology·2026

Same author

Realization of Long Axial Field-of-View PET Technology in the Clinic and Research Environment.

The British journal of radiology·2026

Same author

A Virtual Clinical Trial to Detect Changes in Tumor Uptake with PET using Lesion Embedding.

IEEE transactions on radiation and plasma medical sciences·2026

Same author

Impact of detector parameters and image resolution modeling on dedicated brain PET imaging.

IEEE transactions on radiation and plasma medical sciences·2026

Same author

In vivo imaging of reactive oxygen species after myocardial ischemia-reperfusion injury: a large animal multimodal imaging and transcriptomic study.

bioRxiv : the preprint server for biology·2025

Same journal

Effective contrast-enhanced preprocessing for intracranial artery segmentation in digital subtraction angiography.

Physics in medicine and biology·2026

Same journal

Improving Plan Quality in Adaptive Proton Therapy Using an Interactive Dose Modification Tool.

Physics in medicine and biology·2026

Same journal

Technical Note: Real-Time MLC Control and Latency Measurement Optimization with External Verification.

Physics in medicine and biology·2026

Same journal

Fetus-Specific Hematopoietic Stem Cell Dosimetry Framework for Leukemia-Relevant Target Cells During Prenatal Development.

Physics in medicine and biology·2026

Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026

Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026

See all related articles

This review highlights advancements in positron emission tomography (PET) instrumentation for clinical use. Key improvements include 3D scanning, better scintillators, energy discrimination, and attenuation correction, enhancing diagnostic capabilities.

Area of Science:

Medical Imaging
Nuclear Medicine
Instrumentation Science

Background:

Positron imaging predates computed tomography, with early instrumentation limitations.
Clinical adoption of PET was influenced by factors beyond technical instrumentation.

Purpose of the Study:

To review developments in positron emission tomography (PET) instrumentation for clinical applications.
To discuss improvements in PET scanners, detectors, and data processing techniques.
To explore factors influencing the clinical acceptance of PET technology.

Main Methods:

Review of historical and recent advancements in PET instrumentation.
Analysis of changes in scanner design, scintillator materials, and detector capabilities.
Discussion of techniques for attenuation correction and energy discrimination.

Related Experiment Videos

Main Results:

Significant improvements in PET scanners, moving from septate to fully 3D systems.
Advancements in scintillator technology and energy discrimination capabilities.
Time-of-flight PET imaging shows promise for substantial performance enhancement.

Conclusions:

Continuous innovation in PET instrumentation has significantly enhanced clinical imaging capabilities.
Improvements in 3D scanning, detector technology, and data correction methods are crucial.
Emerging techniques like time-of-flight PET offer future potential for improved diagnostic accuracy.