Related Experiment Video
Updated: Aug 7, 2026

Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening
Published on: July 18, 2012
Antifungal azaphilones from the fungus Chaetomium cupreum CC3003
Somdej Kanokmedhakul1, Kwanjai Kanokmedhakul, Pitak Nasomjai
1Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. somdej@kku.ac.th
Abstract:
Three new azaphilones named rotiorinols A-C (1-3), two new stereoisomers, (-)-rotiorin (4) and epi-isochromophilone II (5), and a known compound, rubrorotiorin (6), were isolated from the fungus Chaetomium cupreum CC3003. Structures were established on the basis of spectroscopic evidence. The absolute configuration of 1 was determined by the modified Mosher's method along with an X-ray analysis of its acetate derivative, as well as by chemical transformation. Compounds 1, 3, 4, and 6 exhibited antifungal activity against Candida albicans with IC50 values of 10.5, 16.7, 24.3, and 0.6 microg/mL, respectively.
Related Concept Videos
Antifungal Agents
Fungal Group Zygomycota
Candidiasis
Fungal Phylum Microsporidia
Fungal Phylum Ascomycota

