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Emmprin (basigin/CD147): matrix metalloproteinase modulator and multifunctional cell recognition molecule that plays

Kazuki Nabeshima1, Hiroshi Iwasaki, Kaori Koga

  • 1Department of Pathology, Fukuoka University Hospital, Fukuoka, Japan. kaznabes@fukuoka-u.ac.jp

Pathology International
|June 24, 2006
PubMed

Insights

Emmprin (basigin, CD147), a cell surface protein, drives tumor progression by stimulating matrix metalloproteinases, angiogenesis, and drug resistance. Understanding its diverse functions is key to developing targeted cancer therapies.

Area of Science:

  • Molecular Biology
  • Oncology
  • Immunology

Background:

  • Emmprin (basigin, CD147) is an immunoglobulin superfamily member highly expressed on tumor cells.
  • It promotes tumor progression by stimulating matrix metalloproteinases, angiogenesis, and multidrug resistance.
  • Emmprin also has roles in T cell activation, nutrient transport, and neural recognition.

Purpose of the Study:

  • To review the role of emmprin in tumor progression.
  • To discuss recent advances in the molecular mechanisms of emmprin-regulated phenomena.
  • To highlight emmprin as a potential target for antitumor therapies.

Main Methods:

  • Literature review of studies on emmprin function and mechanisms.
  • Analysis of emmprin's role in cancer cell biology.
  • Investigation of emmprin's involvement in physiological and pathological processes.

Main Results:

  • Emmprin stimulates matrix metalloproteinase production, leading to tumor invasion.
  • Emmprin promotes angiogenesis via vascular endothelial growth factor stimulation.
  • Emmprin contributes to anchorage-independent growth and multidrug resistance through hyaluronan regulation.

Conclusions:

  • Emmprin is a critical mediator of tumor progression and metastasis.
  • Targeting emmprin offers a promising strategy for novel antitumor treatments.
  • Further elucidation of emmprin's diverse molecular mechanisms is essential for developing specific therapeutic interventions.

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