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Updated: Aug 7, 2026

Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
Published on: July 15, 2019
The homeobox HOXB13 is expressed in human minor salivary gland
C Cazal1, A P V Sobral, F C S de Almeida
1Department of Oral Pathology, University of São Paulo. São Paulo, Brazil.
Background:
Homeobox are a family of developmental genes involved in morphogenesis and cellular differentiation. Participation of homeobox within normal and malignant tissue has been recently discussed in the literature.
Objective:
To analyze the presence of HOXB13 transcript expression in human minor salivary gland.
Material And Methods:
Ten-micrometer sections from frozen samples were evaluated employing non-radioactive in situ hybridization technique and HOXB13 mRNA probes.
Results:
HOXB13 was found to be expressed in ducts and mucous acini but not in serous acini.
Conclusions:
RESULTS suggest that HOXB13 transcripts are differently expressed in normal mucous and serous acini, and it may possibly reflect a different role in salivary gland carcinogenesis.
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