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Updated: Aug 7, 2026
A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
[Study on the association between hantavirus infection and Rattus norvegicus]
Jia-fu Jiang1, Xiao-ming Wu, Shu-qing Zuo
1State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.
Objective:
To further understand the association of hantavirus (HV) harbored and transmitted in wild brown rats.
Methods:
Rattus norvegicus (n = 570) were trapped in 10 sites in Beijing. RT-PCR was used to test rodent lung samples for hantavirus infection. Unconditional multivariate logistic regression analysis was performed, with PCR positive as the dependent variable and the characteristics of Rattus norvegicus population as independent variables.
Results:
The overall HV prevalence in Rattus norvegicus was 9.1% (52/570). Significant association between HV infection in Rattus norvegicus and some biological characteristics of host population was observed. Adult Rattus norvegicus had a higher HV prevalence than juveniles. Males in the reproduction periods and rats with wounds were more likely to be infected with HV than others.
Conclusion:
It was further confirmed that there existed parallel transmission of HV in Rattus norvegicus hosts. Aggression might be the primary mode of HV transmission among male Rattus norvegicus.
