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The effect of PMA-induced differentiation on the surface expression of integrins on CHRF 288-11 megakaryoblastic

N Conran1, F W Hemming

  • 1Department of Biochemistry, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.

Platelets
|June 24, 2006
PubMed

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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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