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Updated: Aug 14, 2026

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo
05:44

The c-FOS Protein Immunohistological Detection: A Useful Tool As a Marker of Central Pathways Involved in Specific Physiological Responses In Vivo and Ex Vivo

Published on: April 25, 2016

[The immunotropic properties of fenazepam]

P F Zabrodskiĭ

    Farmakologiia I Toksikologiia
    |March 1, 1991
    PubMed

    The effect of phenazepam (0.25-10.0 mg/kg) on the humoral immune response, antibody-dependent cellular cytotoxicity (ADCC), the ability of macrophages to induce the humoral immune response at a single administration to Wistar rats and CBA mice was studied. It was found that when administered in doses of 1.0-5.0 mg/kg phenazepam exerts the stimulating effect on the formation of antibodies to the thymus-dependent antigen (ram erythrocytes). When administered in a dose of 2.5 mg/kg the drug increases the titer of antibodies to Vi antigen, ADCC, the ability of macrophages to induce the humoral immune response and also abolishes the studied manifestations of the postintoxication immunodeficiency state caused by anticholinesterase agent.

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