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Updated: Aug 7, 2026

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity
08:45

Isothermal Titration Calorimetry for Measuring Macromolecule-Ligand Affinity

Published on: September 7, 2011

Sertaconazole/hydroxypropyl-beta-cyclodextrin complexation: isothermal titration calorimetry and solubility

Ana I Rodriguez-Perez1, Carmen Rodriguez-Tenreiro, Carmen Alvarez-Lorenzo

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.

Journal of Pharmaceutical Sciences
|June 24, 2006
PubMed
Summary

Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) significantly enhances sertaconazole (SN) solubility and dissolution rates, particularly at acidic pH. This complexation offers a promising approach for improving drug delivery systems.

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