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Published on: June 27, 2025

Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus

Baogang Peng1, Lijian Liang, Qiang He

  • 1Department of Hepatobiliary Surgery, First Affiliated Hospital of Sun Yat-Sen University, 58 Zhongshan Road 2, Guangzhou 510080, China. pengbaogang@tom.com

Hepato-Gastroenterology
|June 27, 2006
PubMed

Insights

Surgical treatment combining liver resection with portal vein tumor thrombus (PVTT) removal, followed by adjuvant portal vein chemotherapy (PVC), significantly improves survival for hepatocellular carcinoma (HCC) patients with PVTT.

Area of Science:

  • Hepatobiliary Surgery
  • Surgical Oncology
  • Gastroenterology

Background:

  • Hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) presents a significant clinical challenge.
  • Surgical intervention for HCC with PVTT is complex and requires careful consideration of treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy of surgical treatment for hepatocellular carcinoma (HCC) involving portal vein tumor thrombus (PVTT).
  • To compare the outcomes of liver resection with PVTT removal alone versus combined with adjuvant portal vein chemotherapy (PVC).

Main Methods:

  • A retrospective study involving 63 HCC patients with PVTT undergoing liver resection and PVTT removal (Group 1) from 1997-2001.
  • A subsequent cohort of 20 HCC patients with PVTT received adjuvant portal vein chemotherapy (PVC) post-surgery (Group 2) from 2001-2003.
  • Comparison of treatment outcomes and survival rates between the two groups.

Main Results:

  • Group 2 (surgery + PVC) demonstrated a significantly longer median overall survival (10.9 months) compared to Group 1 (surgery alone, 7.8 months) (p < 0.05).
  • 1-, 3-, and 5-year survival rates for Group 1 were 18.0%, 14.8%, and 1.6%, respectively.
  • The 1-year survival rate for Group 2 was 30%, indicating a survival benefit.

Conclusions:

  • Liver resection combined with PVTT removal and postoperative PVC offers significant survival benefits for HCC patients with PVTT.
  • Postoperative PVC appears to enhance the effectiveness of surgical treatment for HCC with PVTT.
Abstract

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