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Soft tissue myoepithelial carcinoma.

Zorica Stojsić1, Dimitrije Brasanac, Dragoljub Bacetić

  • 1School of Medicine, Institute of Pathology, Belgrade, Serbia and Montenegro. zstoj@infosky.net

Vojnosanitetski Pregled
|June 27, 2006
PubMed
Summary

This case report details a rare malignant myoepithelioma in the soft tissue. The subcutaneous tumor exhibited high-grade atypia and a myoepithelial immunophenotype, classifying it as soft-tissue myoepithelial carcinoma.

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Area of Science:

  • Oncology
  • Pathology
  • Dermatopathology

Background:

  • Myoepitheliomas are rare tumors primarily affecting salivary glands.
  • Cutaneous or soft tissue myoepitheliomas, particularly malignant forms, are exceptionally uncommon.

Observation:

  • A 62-year-old woman presented with a myoepithelial carcinoma in the subcutaneous adipose tissue of her left forearm.
  • Histological examination revealed epithelioid and hyaline cell types within a hyalinized and myxoid matrix.
  • The neoplasm demonstrated high-grade cytologic atypia, pleomorphic nuclei, prominent nucleoli, scattered giant cells, a high mitotic count, and extensive necrosis.

Findings:

  • Immunohistochemical staining confirmed positivity for cytokeratin (AE1/AE3), epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, and vimentin.

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  • The tumor was classified as a soft-tissue myoepithelial carcinoma based on its subcutaneous location, myoepithelial immunophenotype, and high-grade cytologic atypia.

    • Implications:

    • This case expands the understanding of rare soft-tissue malignancies.
    • Highlights the importance of considering myoepithelial differentiation in subcutaneous tumors with high-grade atypia.
    • Emphasizes the utility of immunohistochemistry in diagnosing challenging soft-tissue neoplasms.