Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The association between apolipoprotein E and multiple sclerosis.

M Pinholt1, J L Frederiksen, M Christiansen

  • 1Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark.

European Journal of Neurology
|June 27, 2006
PubMed
Summary

The apolipoprotein E (Apo E) epsilon4 allele may increase the risk of developing multiple sclerosis (MS). Apo E epsilon4 is linked to faster disease progression in MS patients, but not necessarily to increased relapse rates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Virus antibody responses in patients with myelin oligodendrocyte glycoprotein antibody-associated disease and multiple sclerosis.

Multiple sclerosis and related disorders·2026
Same author

Prenatal detection and outcome of major heart defects in a country with universal screening.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
Same author

Impact of methodological choices in comparative effectiveness studies: application in natalizumab versus fingolimod comparison among patients with multiple sclerosis.

BMC medical research methodology·2022
Same author

Virus-specific antibody indices may supplement the total IgG index in diagnostics of multiple sclerosis.

Journal of neuroimmunology·2022
Same author

Highly sensitive quantification of optic neuritis intrathecal biomarker CXCL13.

Multiple sclerosis and related disorders·2020
Same author

Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

Multiple sclerosis (Houndmills, Basingstoke, England)·2019

Area of Science:

  • Neuroscience
  • Genetics
  • Immunology

Background:

  • Apolipoprotein E (Apo E) plays a crucial role in cholesterol metabolism, vital for nerve tissue repair.
  • Apo E is implicated in neurodegenerative diseases, notably Alzheimer's disease with the Apo E epsilon4 allele.
  • The relationship between Apo E and multiple sclerosis (MS) requires further investigation.

Purpose of the Study:

  • To conduct a comprehensive literature review on the association between apolipoprotein E (Apo E) and multiple sclerosis (MS).
  • To evaluate the impact of the Apo E epsilon4 allele on MS risk, disease progression, and clinical characteristics.

Main Methods:

  • Systematic literature search and review of studies investigating Apo E and MS.
  • Analysis of data concerning Apo E epsilon4 allele presence and its correlation with MS development and progression.

Related Experiment Videos

  • Inclusion of studies utilizing various methodologies, including cross-sectional, longitudinal, and magnetic resonance imaging (MRI) assessments.

    • Main Results:

    • Limited evidence suggests homozygosity for Apo E epsilon4 may increase MS risk; heterozygosity shows no clear association.
    • No consistent links were found between Apo E epsilon4 and MS subgroups, age of onset, or gender.
    • The association between Apo E epsilon4 and MS relapse rate is contradictory.
    • A significant portion of studies indicate that the Apo E epsilon4 allele is associated with increased disease progression in MS, supported by longitudinal data and MRI findings.

    Conclusions:

    • The apolipoprotein E epsilon4 allele is suggested as a potential predisposing factor for faster disease progression in multiple sclerosis.
    • Further research is warranted to elucidate the precise role of Apo E in MS pathogenesis and clinical trajectory.