Related Experiment Video
Updated: Aug 7, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
A case of cerebral Whipple's disease initially presenting with isolated focal myoclonus
S Henning1, T Tings, H Schmidt
1Department of Clinical Neurophysiology, Georg-August University, Göttingen, Germany. henning@medizin.uni-goettingen.de
Abstract:
Neurological manifestations in Whipple's disease are highly variable and tend to occur at later stages of the disease. However, isolated, focal neurological symptoms are reported to be rare. Here we describe the successful treatment of a case of cerebral Whipple's disease initially presenting solely with isolated myoclonic jerks of the left hand and forearm evolving to a segmental myoclonus at a later stage. Additionally, we present - to our knowledge - a novel treatment by administration of immunomodulatory therapy (IVIg) in addition to established antibiotics.
Related Concept Videos
Seizures ll: Types
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Epilepsy ll: Types
Multiple Sclerosis l: Introduction
Seizures l: Introduction
Encephalitis l: Introduction
