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[Correlation of C-reactive protein with activity of Crohn's disease]

Chuan-hua Yang1, Xiao-yu Chen, Feng Yang

  • 1Shanghai Institute of Digestive Disease, Renji Hospital, Shanghai Jiaotong University, Shanghai 200001, China.

Zhonghua Yi Xue Za Zhi
|June 27, 2006
PubMed

Insights

C-reactive protein (CRP) effectively reflects moderate to severe colonic Crohn's disease (CD) activity and drug treatment effects. CRP levels correlate with disease recurrence and NF-kappaB p65 expression in colon tissue.

Area of Science:

  • Gastroenterology
  • Immunology
  • Clinical Chemistry

Context:

  • Crohn's disease (CD) is a chronic inflammatory condition requiring accurate activity assessment.
  • Biomarkers are crucial for monitoring disease progression and treatment efficacy in CD.

Purpose:

  • To evaluate the utility of C-reactive protein (CRP) as a marker for Crohn's disease activity.
  • To assess the correlation of CRP with established disease activity indices and inflammatory markers.

Summary:

  • CRP levels were analyzed in 85 CD patients alongside erythrocyte sedimentation rate (ESR), albumin, hemoglobin, and Crohn's Disease Activity Index (CDAI).
  • CRP elevation correlated with ESR and was significantly higher in active, severe, or colonic CD.
  • CRP levels decreased with effective drug treatment and increased upon recurrence, paralleling NF-kappaB p65 expression.

Impact:

  • CRP is a valuable, accessible biomarker for monitoring moderate to severe colonic CD activity.
  • CRP can indicate treatment response and disease recurrence in early stages of CD.
  • Findings suggest a link between systemic CRP levels and specific molecular pathways (NF-kappaB p65) in CD pathogenesis.
Abstract

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