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[Pancreatic insulinomas].

Franz R Apodaca-Torrez1, Tarcisio Triviño, Edson José Lobo

  • 1Disciplina de Gastroenterología Quirúrgica, Escuela Paulista de Medicina, Universidad Federal de São Paulo, São Paulo, Brasil. apodaca@uol.com.br

Cirugia Espanola
|June 27, 2006
PubMed
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Surgical treatment for insulinoma, the most common pancreatic neuroendocrine tumor, effectively resolves hypoglycemia and hyperinsulinemia. All patients experienced symptom reversion post-surgery, with pancreatic fistula being the most frequent complication.

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Gastroenterology

Context:

  • Insulinoma is the most common pancreatic neuroendocrine tumor.
  • Characterized by hyperinsulinemia and hypoglycemia, leading to Whipple's triad.
  • Surgical intervention is the primary treatment modality.

Purpose:

  • To evaluate the clinical and immunohistochemical outcomes of surgically treated insulinoma patients.
  • To analyze surgical techniques, complications, and long-term follow-up.
  • To assess the efficacy of surgery in symptom resolution.

Summary:

  • Twenty patients with insulinoma underwent surgical treatment between 1986 and 2004.
  • Preoperative localization was achieved in 15 patients; intraoperative methods were used for the remaining 5.

Related Experiment Videos

  • Surgical procedures included pancreatic resection (10) and enucleation (10); laparoscopy was used in 2.
  • The most common complication was pancreatic fistula; no mortality was observed.
  • All patients achieved symptom reversion, with normalized glycemia post-surgery.
  • Impact:

    • Surgical management of insulinoma demonstrates high efficacy in achieving symptom resolution.
    • Understanding surgical outcomes and complications aids in optimizing patient care.
    • This study contributes to the long-term data on surgical treatment for pancreatic neuroendocrine tumors.