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A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
Published on: July 21, 2023
Unusual case of an 18-year-old heart transplant recipient with endocardial fibroelastosis
U Fuchs1, A Zittermann, U Schulz
1Heart Center North-Rhine Westfalica, Department of Cardio-Thoracic Surgery, Ruhr University of Bochum, Bad Oeynhausen, and Department of Pathology, Municipal Hospital of Bielefeld, Germany. ufuchs@hdz-nrw.de
Abstract:
An 18-year-old female Japanese patient who suffered from heart failure and severe pulmonary hypertension was referred to our clinic. The etiology of her cardiomyopathy was unclear. Inhaled prostacyclin therapy resulted in an improvement of pulmonary arterial pressure and allowed us to avoid lung transplantation. Heart transplantation resulted in a complete remission of her respiratory function. Autopsies of the explanted heart revealed massive endomyocardial fibroelastosis. We concluded that endomyocardial fibroelastosis has to be considered a cause of heart failure in young adults with unclear cardiomyopathy.
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