Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

When transcription and repair meet: a complex system.

Jean-Philippe Lainé1, Jean-Marc Egly

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, BP 163, 67404 Illkirch Cedex, C. U. Strasbourg, France.

Trends in Genetics : TIG
|June 27, 2006
PubMed
Summary

Transcription-coupled repair (TCR) removes DNA damage to allow gene transcription. This review details the repair process, focusing on CSA and CSB proteins crucial for TCR and linked to Cockayne syndrome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TOP2 and NOS2 Orchestrate the Generation of DNA Breaks to Promote Colitis Cancer Initiation.

Cancers·2026
Same author

Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity.

Nature communications·2025
Same author

Unveiling the Mechanism of Lurbinectedin's Action and Its Potential in Combination Therapies in Small Cell Lung Cancer.

Molecular cancer therapeutics·2024
Same author

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress.

Nature communications·2023
Same author

XPF activates break-induced telomere synthesis.

Nature communications·2022
Same author

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary.

Aging·2022

Area of Science:

  • Molecular Biology
  • Genetics
  • DNA Repair Mechanisms

Background:

  • Transcription-coupled repair (TCR) is vital for maintaining genome stability by removing DNA lesions that impede transcription.
  • The precise molecular cascade of TCR events, from lesion recognition to repair completion, is not fully elucidated.
  • Defects in TCR are associated with Cockayne syndrome, a rare genetic disorder characterized by premature aging and developmental abnormalities.

Purpose of the Study:

  • To review and illustrate the sequential events involved in transcription-coupled repair.
  • To highlight the critical roles of CSA and CSB proteins in the TCR pathway.
  • To connect defective TCR, caused by mutations in CSA or CSB, to the pathogenesis of Cockayne syndrome.

Main Methods:

  • Literature review of existing research on transcription-coupled repair.

Related Experiment Videos

  • Analysis of the functional roles of CSA and CSB proteins in DNA repair and transcription.
  • Integration of current knowledge to propose a model for the TCR pathway.

    • Main Results:

    • Detailed illustration of the proposed step-by-step mechanism of TCR.
    • Emphasis on the involvement of CSA and CSB proteins in recognizing DNA damage during transcription.
    • Explanation of how mutations in CSA and CSB lead to impaired TCR and cellular dysfunction.

    Conclusions:

    • TCR is an essential pathway for removing transcription-blocking DNA lesions.
    • CSA and CSB proteins are key players in the TCR machinery, mediating damage recognition and repair.
    • Understanding TCR mechanisms, particularly the roles of CSA and CSB, is crucial for comprehending Cockayne syndrome and developing potential therapeutic strategies.