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Related Experiment Videos

The coordinated evolution of yeast proteins is constrained by functional modularity.

Yiwen Chen1, Nikolay V Dokholyan

  • 1Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Trends in Genetics : TIG
|June 27, 2006
PubMed
Summary

Functional modularity constrains protein evolution. Proteins in the same functional modules show similar rates of sequence and expression evolution, suggesting coordinated changes driven by cellular system organization.

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Area of Science:

  • Evolutionary biology
  • Systems biology
  • Molecular biology

Background:

  • Functional modularity is crucial for cellular systems and evolution.
  • The impact of functional modularity on protein evolution remains poorly understood.

Purpose of the Study:

  • To investigate how functional modularity influences the evolutionary rates of protein sequences and expression levels.
  • To determine if proteins within functional modules exhibit coordinated evolutionary patterns.

Main Methods:

  • Analysis of protein sequence evolution in Saccharomyces cerevisiae.
  • Analysis of protein expression level evolution in Saccharomyces cerevisiae.
  • Comparative analysis of evolutionary rates within and between functional modules.

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Main Results:

  • Proteins within the same functional modules evolve at more similar rates compared to proteins in different modules.
  • Stronger co-evolution of expression levels was observed between proteins within functional modules.
  • Evidence suggests functional modularity imposes constraints on coordinated protein evolution.

Conclusions:

  • Functional modularity plays a significant role in shaping protein evolution.
  • Both sequence and expression levels of proteins evolve in a coordinated manner, influenced by functional modules.
  • This coordinated evolution is constrained by the modular organization of cellular systems.