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Updated: Aug 7, 2026

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
CGRP stimulates gill carbonic anhydrase activity in molluscs via a common CT/CGRP receptor
Benoit Cudennec1, Marthe Rousseau, Evelyne Lopez
1UMR 5178 CNRS/MNHN/UPMC, Muséum National d'Histoire Naturelle, Station Biologie Marine, 29900 Concarneau, France.
Abstract:
The physiological significance of calcitonin gene-related peptide (CGRP) during biomineralization was investigated by assessing the effect of human CGRP on the carbonic anhydrase activity in gill membranes of the pearl oyster, Pinctada margaritifera. Salmon CT and human CGRP were able to induce a 150% increase of the basal activity. No additive effect was observed suggesting that both activities are mediated by the same receptor. The CGRP-stimulated effect was specific as demonstrated by the inhibition produced by the CGRP antagonist, hCGRP8-37. So, CGRP by its specific action on gill carbonic anhydrase controls the calcification process, an ancient role both in invertebrates and non-mammalian vertebrates.
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