Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abrupt changes in antibiotic resistance.

J E McGowan1

  • 1Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia.

The Journal of Hospital Infection
|June 11, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cooking fuel type, household ventilation, and the risk of acute lower respiratory illness in urban Bangladeshi children: a longitudinal study.

Indoor air·2011
Same author

Rainfall, household crowding, and acute respiratory infections in the tropics.

Epidemiology and infection·2011
Same author

Effect of setting a maximum milking time, from peak lactation, on production, milking time and udder health.

New Zealand veterinary journal·2010
Same author

Quantitative analysis and molecular fingerprinting of methicillin-resistant Staphylococcus aureus nasal colonization in different patient populations: a prospective, multicenter study.

Infection control and hospital epidemiology·2010
Same author

Longitudinal analysis of community health workers' adherence to treatment guidelines, Siaya, Kenya, 1997-2002.

Tropical medicine & international health : TM & IH·2007
Same author

The influence of observation and setting on community health workers' practices.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2006
Same journal

Diagnostic Stewardship for optimizing blood culture practices: A Systematic Review of clinical practice guidelines and evidence-based recommendations.

The Journal of hospital infection·2026
Same journal

Identification of risk factors for hospital-onset bacteremia to inform a routine data based risk prediction - an umbrella review.

The Journal of hospital infection·2026
Same journal

Healthcare-associated Infections in the Middle East: A Systematic Review and Meta-Analysis of Point-Prevalence Studies.

The Journal of hospital infection·2026
Same journal

Expression of concern: Postoperative serum amyloid A as a primary marker in a predictive model for ventilator-associated pneumonia in elderly patients with acute ischaemic stroke undergoing endovascular therapy with general anaesthesia [Journal of Hospital Infection, pre-proof, available online 8 July 2025].

The Journal of hospital infection·2026
Same journal

Past lessons for the 2026 Bundibugyo virus outbreak: filovirus infection prevention in conflict-affected settings.

The Journal of hospital infection·2026
Same journal

Global randomised controlled trials in infection prevention and control: a bibliographic review from the past two decades.

The Journal of hospital infection·2026
See all related articles

Antimicrobial resistance in bacteria can increase suddenly due to various mechanisms. Understanding these resistance pathways is crucial for effective infection control and treatment strategies.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Sudden increases in antimicrobial resistance are observed in both hospital-acquired and community-acquired infections.
  • Examples include rapid changes in susceptibility to amikacin, increased beta-lactamase-producing Neisseria gonorrhoeae, and widespread ciprofloxacin resistance in methicillin-resistant Staphylococcus aureus.

Purpose of the Study:

  • To explore the mechanisms behind abrupt increases in antimicrobial resistance.
  • To highlight the importance of rapid identification of resistance mechanisms for effective infection control.

Main Methods:

  • Postulation of four primary mechanisms for resistance development (excluding laboratory artifacts).
  • Analysis of abrupt resistance changes in bacterial pathogens like Neisseria gonorrhoeae and Staphylococcus aureus.

Related Experiment Videos

  • Consideration of genetic mutation, horizontal gene transfer, and selection of resistant subpopulations.

    • Main Results:

    • Four key mechanisms contribute to sudden antimicrobial resistance: introduction of resistant organisms, genetic acquisition of resistance, emergence of dormant mechanisms, and selection of resistant subpopulations.
    • These mechanisms can lead to rapid increases in resistance when prevalent or widely disseminated.
    • Organisms are expected to continue evolving novel resistance strategies.

    Conclusions:

    • Prompt identification of resistance mechanisms by infection control personnel is essential for implementing appropriate interventions.
    • Newer organism typing methods can aid in identifying specific resistance mechanisms in clinical settings.
    • Effective management requires understanding and addressing the diverse ways bacteria develop resistance.