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Hospital outbreaks with yeasts.

W Lee1, J P Burnie, R C Matthews

  • 1Department of Medical Microbiology, University of Manchester Medical School, UK.

The Journal of Hospital Infection
|June 1, 1991
PubMed
Summary

This study reviews Candida albicans outbreaks and presents a new neonatal unit outbreak. DNA typing methods were used to define Torulopsis glabrata outbreaks, which resulted in five deaths.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Disseminated candidosis, often caused by Candida albicans, poses a significant threat, particularly in neonatal units.
  • Previous outbreaks highlight the challenges in controlling and defining yeast infections.

Purpose of the Study:

  • To review previous outbreaks of disseminated candidosis.
  • To present a new outbreak of Candida albicans infection in a neonatal unit.
  • To discuss the utility of typing methods in defining and controlling yeast outbreaks, including Torulopsis glabrata.

Main Methods:

  • Review of historical outbreak data.
  • Case presentation of a new neonatal unit outbreak involving Candida albicans.
  • Application of morphologic, immunoblot, and DNA typing for outbreak definition.
  • DNA fingerprinting using the enzyme Xba for Torulopsis glabrata outbreak identification.

Main Results:

  • Four disseminated cases of Candida albicans infection were identified in the new outbreak.
  • An outbreak of Torulopsis glabrata involving 23 patients was defined using DNA fingerprinting.
  • Five deaths were attributed to yeast infections, either fully or partially.

Conclusions:

  • Accurate typing methods, especially DNA fingerprinting, are crucial for defining and controlling nosocomial yeast outbreaks.
  • Candida albicans and Torulopsis glabrata represent significant etiological agents in hospital-acquired infections.
  • Prompt identification and control measures are essential to mitigate mortality associated with disseminated yeast infections.

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