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Angiogenesis in multiple myeloma.

Christian Jakob¹, Jan Sterz, Ivana Zavrski

¹Department of Haematology and Oncology, Charité, Universitätsmedizin Berlin, Schumannstr. 20, D-10117 Berlin, Germany.

European Journal of Cancer (Oxford, England : 1990)

|June 27, 2006

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Multiple myeloma involves increased blood vessel growth, or angiogenesis, which may fuel cancer cell proliferation. This review highlights how bone marrow microenvironment supports myeloma angiogenesis and tumor growth.

Area of Science:

Hematology
Oncology
Cancer Biology

Background:

Multiple myeloma (MM) is a hematological malignancy.
Bone marrow microvessel density (MVD) has prognostic relevance in MM.
Myeloma-induced angiogenesis involves myeloma cells, stromal cells, or endothelial cells (EC).

Purpose of the Study:

To review recent data on angiogenesis in the bone marrow microenvironment of MM patients.
To explore the role of angiogenesis in promoting plasma cell (PC) growth in MM.

Main Methods:

Review of recent scientific literature.
Analysis of data on angiogenic factors and microvessel density in MM.
Correlation of angiogenic factors with disease stage and prognosis.

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Main Results:

Increased angiogenic potential and paracrine stimulatory effects of bone marrow EC on PC in MM.
Elevated soluble angiogenic factors (bFGF, HGF, VEGF) in bone marrow and peripheral blood.
Correlation between serum levels of angiogenic factors and MM disease stage/prognosis.

Conclusions:

Strong evidence supports increased angiogenic activity in the bone marrow microenvironment in MM.
Angiogenesis may actively promote plasma cell growth in multiple myeloma, not just be a byproduct of tumor growth.