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Published on: January 2, 2017

Efficacy/safety of amoxicillin/clavulanate in adults with bacterial rhinosinusitis

Jack B Anon1, Elchonon Berkowitz, John Breton

  • 1Department of Otolaryngology, University of Pittsburgh College of Medicine, Erie, PA 16508, USA. janonmd@velocity.net

American Journal of Otolaryngology
|June 27, 2006
PubMed
Abstract

Insights

This study shows that amoxicillin/clavulanate 2000/125 mg effectively treats acute bacterial rhinosinusitis (ABRS), even against resistant strains. The enhanced formulation offers a good option for adult ABRS patients.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Otolaryngology

Background:

  • Acute bacterial rhinosinusitis (ABRS) is a common condition often caused by Streptococcus pneumoniae and Haemophilus influenzae.
  • Increasing antibacterial resistance in respiratory pathogens is a significant clinical concern.
  • A novel pharmacokinetically enhanced amoxicillin/clavulanate formulation (2000/125 mg) was developed to address resistant strains.

Purpose of the Study:

  • To assess the bacteriologic and clinical efficacy of amoxicillin/clavulanate 2000/125 mg in adult patients diagnosed with ABRS.
  • To evaluate the effectiveness of this enhanced formulation against common respiratory pathogens, including resistant strains.

Main Methods:

  • An open-label, noncomparative study design was employed.
  • Adult patients with clinically and radiologically confirmed ABRS were enrolled.
  • Sinus puncture was performed at study entry for bacteriologic assessment.

Main Results:

  • Bacteriologic success was achieved in 87.8% of patients with isolated pathogens.
  • High success rates were observed against Streptococcus pneumoniae (93.2%) and penicillin-resistant S. pneumoniae (96.7%).
  • Effectiveness was also demonstrated against beta-lactamase-positive pathogens (88.7%).

Conclusions:

  • Amoxicillin/clavulanate 2000/125 mg was well-tolerated in the study population.
  • This enhanced formulation represents a viable therapeutic option for empiric treatment of ABRS in adults.
  • The study supports the use of this formulation in managing ABRS, considering rising antimicrobial resistance.

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