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Thyroglobulin in human thyroid follicles with acid mucin
1Department of Pathology, University of Wales College of Medicine, Cardiff, U.K.
The Journal of Pathology
|July 1, 1991
Summary
Certain thyroid follicles containing acid mucin are linked to the ultimobranchial body. This study found evidence supporting the ultimobranchial origin of some C cells and follicular cells in the thyroid gland.
Area of Science:
- Endocrinology
- Cell Biology
- Histology
Background:
- A subset of human thyroid follicles contain acid mucin and are located in the C-cell area.
- These unique follicles are lined by abundant C cells and are hypothesized to originate from the ultimobranchial body.
Purpose of the Study:
- To investigate the cellular and molecular characteristics of ultimobranchial-related thyroid follicles.
- To determine if these follicles contain components typically associated with both C cells and follicular cells.
Main Methods:
- Immunohistochemical analysis was performed on thyroid tissue sections.
- Detection of thyroglobulin, calcitonin, and CGRP (calcitonin gene-related peptide) was utilized.
Main Results:
- Thyroglobulin-reactive follicular cells and colloid were identified within these specific thyroid follicles.
- Calcitonin and CGRP, markers of C cells, were also present in these ultimobranchial-related follicles.
Conclusions:
- The presence of both follicular cell and C cell markers supports the origin of these follicles from the ultimobranchial body.
- These findings suggest that the ultimobranchial stem cell line may be the source of thyroid mixed medullary follicular neoplasia.