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[Toxic hepatitis from cinchophen: report of 3 cases]
C Cutrín Prieto1, E Nieto Pol, A Batalla Eiras
1Servicio de Medicina Interna Hospital General de Galicia-Gil Casares, Santiago de Compostela, La Coruña.
Medicina Clinica
|June 15, 1991
Summary
Cincophen, a uricosuric drug, can cause severe liver damage (hepatic necrosis) and failure, even death. This report highlights these risks to prevent future cases of drug-induced liver injury.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Toxicology
Background:
- Cincophen is a uricosuric agent historically used for gout and urate stones.
- Drug-induced liver injury (DILI) remains a significant clinical challenge.
Observation:
- Three cases of severe hepatic toxicity in women treated with cincophen for renoureteral urate stones are presented.
- Patients developed acute hepatitis, with one case progressing to fatal hepatic failure.
- Histologic findings suggest hepatic necrosis via hypersensitivity or metabolic idiosyncrasy.
Findings:
- Cincophen-induced hepatotoxicity is a serious adverse drug reaction.
- The mortality rate associated with severe cincophen hepatotoxicity can be as high as 50% in reported cases.
- Mechanisms of injury are similar to other known hepatotoxic agents like isoniazid and halothane.
Implications:
- Clinicians should be aware of the severe hepatotoxic potential of cincophen.
- Preventing new cases requires recognizing the risks and considering safer alternatives.
- Continued availability of cincophen in some regions necessitates heightened vigilance and patient monitoring.