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Nefopam HCl interaction study with eight other drugs
The Journal of International Medical Research
|January 1, 1976
Summary
This study assessed drug interactions of nefopam hydrochloride (HCl) with eight common medications. Nefopam HCl showed no significant interaction, supporting its short-term use with these drugs.
Area of Science:
- Pharmacology
- Clinical Trials
- Drug Interactions
Background:
- Nefopam hydrochloride (HCl) is a novel analgesic.
- Assessing potential drug interactions is crucial for patient safety.
Purpose of the Study:
- To evaluate the drug interaction potential of nefopam HCl when co-administered with eight commonly used medications.
- To detect interactions through side-effects, bioavailability, vital signs, and laboratory tests.
Main Methods:
- A controlled clinical trial involving forty-five healthy volunteers in nine groups.
- Subjects received nefopam HCl in combination with other drugs or placebo.
- Drug interactions were monitored via side-effects, serum levels, vital signs, and lab tests.
Main Results:
- No statistically significant differences in measured parameters were observed between nefopam HCl-placebo and combination regimens.
- Serum nefopam HCl levels increased from Day 1 to Day 3, indicating no bioavailability defect.
- Clinical differences in side-effect incidence and intensity were noted with codeine, pentazocine, and propoxyphene combinations, warranting further investigation.
Conclusions:
- Concomitant use of nefopam HCl with the eight tested drugs appears feasible for short treatment durations.
- Further studies are recommended for combinations involving codeine, pentazocine, and propoxyphene due to observed side-effect variations.