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Related Experiment Videos

Accommodative lens refilling in rhesus monkeys.

Steven A Koopmans1, Thom Terwee, Adrian Glasser

  • 1Department of Ophthalmology, University Medical Center Groningen, University of Groningen, The Netherlands. s.a.koopmans@ohk.azg.nl

Investigative Ophthalmology & Visual Science
|June 27, 2006
PubMed
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Restoring accommodation in primate eyes is possible by refilling the lens capsule with a new polymer. This study in rhesus monkeys showed potential for restoring vision with a specific treatment protocol.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Regenerative Medicine

Background:

  • Presbyopia, or age-related loss of accommodation, affects millions globally.
  • Current treatments for presbyopia are limited and often invasive.
  • Restoring the natural accommodative function of the eye is a significant challenge.

Purpose of the Study:

  • To evaluate the efficacy of a novel polymer for restoring accommodation in primate eyes.
  • To assess the safety and feasibility of lens refilling in a rhesus monkey model.
  • To investigate a treatment protocol to minimize inflammation and capsular opacification.

Main Methods:

  • Nine adolescent rhesus monkeys received lens capsular bag refilling with a polymer.
  • Two groups received different post-operative treatment protocols involving corticosteroids.

Related Experiment Videos

  • Accommodation was measured using carbachol iontophoresis or pilocarpine and refractometry over 37 weeks.

    • Main Results:

    • The treatment protocol in group B minimized inflammation and allowed for refraction measurements throughout the study.
    • Monkeys in group B achieved a maximum accommodative amplitude of 6.3 D.
    • While some monkeys showed decreased accommodation over time, two maintained +/-4 D.

    Conclusions:

    • Lens refilling with a polymer can restore a degree of accommodation in primate eyes.
    • A specific treatment protocol is crucial for managing inflammation and enabling functional assessment.
    • This study supports the potential of polymer-based lens refilling for presbyopia treatment.